Press releases for Phase 2 clinical trial topline results: Have the objective pre-specified efficacy results been disclosed?
نویسندگان
چکیده
منابع مشابه
Could HERA results have been predicted from semileptonic meson decays
The anomalous value of the tensor form factor in the kaon decay K → πeν and the destructive interference in pion decay π− → e−ν̄γ can be simultaneously described by admixture of a tensor interaction in the standard V -A one. It is shown that the same tensor interaction can describe recent HERA data at very large Q. 1 On leave from Centre for Space Research and Technologies, Faculty of Physics, U...
متن کاملDiscounting phase 2 results when planning phase 3 clinical trials.
Sample size planning is an important design consideration for a phase 3 trial. In this paper, we consider how to improve this planning when using data from phase 2 trials. We use an approach based on the concept of assurance. We consider adjusting phase 2 results because of two possible sources of bias. The first source arises from selecting compounds with pre-specified favourable phase 2 resul...
متن کاملHemoglobin And Hematocrit Rise In End-Stage Renal Disease (ESRD) With PDpoetin: Results Of A Phase Ш, Multicenter Clinical Trial
Background and Objective: The anemia of ESRD is a complex disorder, associated with serious complications, which increases patients’ mortality and morbidity. Treatment of this anemia with recombinant human erythropoietin (rh-EPO) is well established. This clinical trial study was conducted within 20 months, from May 2005 to December 2006, in order to evaluate the efficacy of PDpoetin (rh-EPO...
متن کاملSome results on pre-monotone operators
In this paper, some properties of pre-monotone operators are proved. It is shown that in a reflexive Banach space, a full domain multivalued $sigma$-monotone operator with sequentially norm$times$weak$^*$ closed graph is norm$times$weak$^*$ upper semicontinuous. The notion of $sigma$-convexity is introduced and the relations between the $sigma$-monotonicity and $sigma$-convexity is i...
متن کاملInterpretation of clinical trial results
Evidence from clinical trials is fundamental to ethical medical practice. Along with patient preferences, circumstances, and clinical experience, it is central to effective clinical decision-making. Applying evidence to clinical questions requires filtering in the form of three questions: first, do the trial results reflect true effects of intervention, rather than artifactual ones (validity)? ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Contemporary Clinical Trials Communications
سال: 2016
ISSN: 2451-8654
DOI: 10.1016/j.conctc.2016.11.001